Â鶹ֱ²¥ researchers are using computer models to better understand how molecules in our cells interact with each other and the role they play in cancer and viral infections.<\/p>\n
Professor Ricardo Mancera, Head of the Biomolecular Modelling Group at the Western Australian Biomedical Research Institute, part of the Faculty of Health Sciences at Â鶹ֱ²¥, is studying interactions between complex carbohydrates and cell receptors and how they may be controlled to alter strength and selectivity.<\/p>\n
Professor Mancera said complex carbohydrates, or sugar molecules, present in our cells mediate a lot of physiological phenomena.<\/p>\n
\u201cWe are interested in processes that happen in our immune system such as inflammation and allergies, as well as cancer and viral infections,\u201d Professor Mancera said.<\/p>\n
The researchers are working to establish the relationship between chemical structure and function to understand how these molecules operate and bind to receptors.<\/p>\n
\u201cOnce you have naturally-occurring molecules with specific physiological roles, then you can try to make small molecule mimics that can be synthesised in the laboratory and have a similar, therapeutic role,\u201d he said.<\/p>\n
\u201cUsing high performance computer modelling, we can predict subtle changes to their chemical structures that may make these mimics more active or more selective.\u201d<\/p>\n
Ultimately, this type of research can lead to a greater understanding of cell interactions at the molecular level and has the potential for drug discovery against a range of inflammatory and allergic diseases, cancer, and parasitic and viral infections.<\/p>\n
Notes to Editor:<\/strong><\/p>\n The Curtin Health Innovation Research Institute Biomedical Sciences precinct<\/strong><\/p>\n The $25 million refurbishment will provide the Curtin Health Innovation Research Institute (CHIRI) with state-of-the-art research, teaching and learning facilities. Opening in 2012, the redevelopment centralises biomedical research on Curtin\u2019s Bentley Campus. It will also provide a new pharmacy simulation laboratory, offices, teaching and student common areas. The building is a key element of Â鶹ֱ²¥\u2019s commitment and vision to rate as one of the top 20 universities in Asia by 2020.<\/p>\n Contact:<\/strong><\/p>\n Teresa Belcher\/Kristy Jones, Public Relations, Â鶹ֱ²¥ Ricardo Mancera, Professor, Biomolecular Modelling Group, School of Pharmacy and School of Biomedical Sciences, Faculty of Health Sciences
\n<\/strong>Tel: 08 9266 9085; Mobile: 402 517 300 Email: teresa.belcher@curtin.edu.au<\/a> \/ k.jones@curtin.edu.au<\/a><\/p>\n
\n<\/strong>Tel: 08 9266 1017; Email r.mancera@curtin.edu.au<\/a><\/p>\n