New Â鶹ֱ²¥-led research has discovered that using drugs to target a pathway in the body that causes cancerous cells to spread aggressively may help to reduce the severity of bladder cancer.<\/p>\n
The research, published in the prestigious journal Nature Communications<\/em>, aimed to understand the function of two naturally occurring proteins called hepatocyte growth factor (HGF) and c-Met that are produced in bladder cancer patients and are associated with poor prognosis, cancer invasion and spreading.<\/p>\n Lead Australian author Associate Professor Pieter Eichhorn, from the Curtin Health Innovation Research Institute (CHIRI) and the School of Pharmacy and Biomedical Sciences at Â鶹ֱ²¥, said bladder cancer was one of the most common causes of cancer-related deaths worldwide and one of the most expensive to treat.<\/p>\n \u201cApproximately 25 per cent of bladder cancer initially presents as muscle-invasive bladder cancer, which is when the cancer cells have spread beyond the inner lining of the bladder and into the muscle layer. Treatment of muscle-invasive bladder cancer remains a major clinical challenge, as the only treatment is the removal of the entire bladder with or without chemotherapy,\u201d Associate Professor Eichhorn said.<\/p>\n \u201cIn mouse models, our team discovered that the HGF and c-Met proteins stimulate a pathway that leads to the release of cancer cells to the blood vessels and the lymphatic system, potentially resulting in the spreading of the primary tumour to other parts of the body.<\/p>\n \u201cWe found that by utilising drugs that inhibit the pathway, it can completely block bladder cancer cells from spreading to surrounding tissues.\u201d<\/p>\n Associate Professor Eichhorn said the findings have potentially significant implications for the future treatment of patients with early stage bladder cancer, but clinical trials are needed to see if this is also effective in human patients.<\/p>\n \u201cBladder cancer continues to impact thousands of Australians each year, so it is critical to conduct high-quality research that may help target this disease and offer future hope for those who have been impacted,\u201d Associate Professor Eichhorn said.<\/p>\n The research was co-authored by researchers from the National University of Singapore.<\/p>\n